2. Franklin and Jane Pierce
Jane was very against Franklin’s political career, demanding that he resign his US Senate seat (which he did) and then fainting at the news that the Democrats had nominated him as their Presidential candidate in 1852.
She openly opposed Franklin’s decision to run for president and the two grew apart before their son Benjamin’s death in a train accident. Jane attributed Benjamin’s death to God being mad at Franklin for his political ambitions. For two years after Franklin’s inauguration, Jane remained in her room, writing letters to her dead son.